The common problem for ignition misfires are ignition coils going bad. Replacement of the bad ignition coil is necessary. These should be fixed as soon as a problem is detected. Otherwise the misfire can cause damage to other components.
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Repairpal verified 2005 Ford Escape problems
The DPFE (differential pressure feedback EGR) sensor tends to fail. The DPFE sensor monitors function of the EGR valve by measuring pressure changes in the exhaust gas recirculation (EGR) system. Symptoms of a failing DPFE sensor are hesitation or stumbling when driving along with illumination of the Check Engine Light.
An abnormal noise may develop from the transfer case. At this time parts are not available to repair internal damage to this type of transfer case, replacement is the only option. It is not uncommon for irregular tire wear to cause a similar noise. Diagnoses should be performed to confirm the actual cause of the driveline noise. Tire noise can be reduced by rotating the tires at least every 5000 miles.