The crankshaft position sensor may fail. Symptoms of this are: The engine will crank—but not start—especially when the engine is warm. The car may start again if it is left to cool off, but it may run roughly or have poor performance.Google+
Car Problem Reports
Mercedes-Benz E430 Engine Performance Problems Due to Crankshaft Position Sensor Failure
Mercedes-Benz E430 Problem
Average Mileage: 140,675 mi (120,000 mi - 183,000 mi)
Visitor, 2001 Mercedes-Benz E430, 126,700 mi
same as described, had to have it towed of MB dealer to be replaced
Visitor, 2001 Mercedes-Benz E430, 183,000 mi
engine cranks but will not start. After an hour or so it starts and continues to start even if hot. It has been suggested that the fuel filter may be old and needs to be replaced. This starting problem has only happened three times in the last year. The check engine light also came on when I did get the car started.
Visitor, 2001 Mercedes-Benz E430, 120,000 mi
Stopped at a red light...Turned Green car died. Wouldnt restart...2 men pushed my car to a nearby parking lot. Later that evening it did start after it had cooled off.