Electrical malfunctions on 2005 Mercedes-Benz C320 4MATIC

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On several occassions, while using the navigation system, the navigation and radio went dead, warning message that there was an error with the display, and the car lost power to the wheels (although engine responded). Each time (so far), shut engine off and restart.. problem is resolved. This sounds to me like a component overheat problem but it is affecting the car's drivability - has anyone else had this issue? What is the fix and how costly is it?
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First and foremost, you need to have all of your computer systems scanned, to get a record of the malfunction. Then once you have that you can have it Diagnosed and then a repair estimate can be created. This sounds like some central electrical module, possibly the Transmission/4-matic Computer is acting up, like you suggested it may be due to heat building up and a mother board is glitching, but since your vehicle has about 50 computers, you will need to have all of those scanned.
Sometimes the solder joints or even the silicone develops little that cracks that cause malfunctioning when the Computer really heats up. Did you have your heat on?
By the way, a properly operating system should never do this, this is a sign that a system is beginning to fail and is becoming heat sensitive.
Thanks for the response... I will arrange to have the local MB dealer scan the computer systems to isolate the malfunction. By the way, yes, we had the heat on in the car when this problem occured. Several times in the past, the navigation and radio went dead but I was able to turn them on again after they cooled off. This time, however, everything on the dash went haywire but the strangest symptom had to do with the driving performance, not the electrical system displays... as I accelerated, the engine responded but the car didn't... like the transmission was slipping. When I put it into reverse, it behaved like I was in neutral. When I shifted it into park, it locked up and I couldn't move the shifter. That's when I turned off the engine and restarted it... and then everything was OK, although it took a while for the navigation to resolve. You may be correct in that this is a problem with the transmission/4-matic computer. I have no idea where the mother board is located... but my wife told me that the dash was hot to the touch when it happended again this evening while she was driving on business. I appreciate your feedback. Thanks again.