Cylinder 2 is misfiring and idles rough on 2001 Chrysler Town & Country

Already did oil change amd change spark plugs and wires. What else could it be?

Is it misfiring all the time or only at idle? If it is only at idle a vacuum leak could be an issue, but you still have to consider that you could have a problem with the injector or compression. You're going to have to get some testing done to find the cause.