CYLINDER 1&3 NOT FIRING on 1999 Ford Escort

Didn't pass emissions test today. Paper states cylinders 1&3 are not firing. Will a tune-up fix that problem? I had my brother do new wires and plugs not to long ago. Admittedly it does not have it's normal power ever since.

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1 answer
start with a compression test to verify the integrity of the motor.

Roy