CYLINDER 1&3 NOT FIRING on 1999 Ford Escort

Didn't pass emissions test today. Paper states cylinders 1&3 are not firing. Will a tune-up fix that problem? I had my brother do new wires and plugs not to long ago. Admittedly it does not have it's normal power ever since.

Asked by for the 1999 Ford Escort
start with a compression test to verify the integrity of the motor.