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computer readout says random ignition on cylinders 1&4. What is most likely fix? on 1999 Buick Park Avenue

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Car runs but mileage has dropped from 32mpg to 18-20 mpg. Cylingers cause terrible idling and difficult to start from the stop sign due to no power. Engine vibrates due to cylinders not firing. He needs car for a couple of hours to diagnos problem but can't get car in for 10 days.
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