The door for the vanity mirror (or the frame for the door) can break; due to a redesign, the mirror "cassette" will need replacement.
Resources for the Repair and Maintenance of your 2006 Mercedes-Benz S500 4MATIC
2006 Mercedes-Benz S500 4MATIC
2006 Mercedes-Benz S500 4MATIC Problems
The relay which turns the airmatic suspension pump on may fail causing the pump to run continuously. This can result in failure of the pump motor or a dead battery as the pump motor will continue to run after the car is turned off. Also, Worn airmatic pump mount bushings can causes noises in the front axle while driving on bumpy roads or a buzzing noise while the pump is running.
A door control module/actuator may fail. Our technicians recommend finding an expert to repair them. Taking the door trim panels off requires expert knowledge because they can break and the pieces are very expensive.
The center console armrest can break. Replacement is commonly the recommended repair.
Front thrust arm and control arm bushings can crack and sometimes tear completely. If this is not repaired quickly, damage to the front subframe unit will occur, which is very expensive to repair. Updated control arms (that prevent damage to the subframe when the bushings wear out) are available.
2006 Mercedes-Benz S500 4MATIC Questions and Answers
How much for a 52000 mile checkup?
i dont see any warrnig only i see tyre presser monitor and indicator light i need help
it is a4matic s 500 automatic and i see no warrning on the instrument and only tyre pressurer monitor indicats and indicator light is on i need un idea
all my electrical is going haywire and screen flashing display not good. lights,door locks, ignition,
Heat stays on and become very hot.