Failed spark plug wires and/or ignition coils can cause intermittent misfires (rough running); the Check Engine Light may also illuminate. Diagnoses of the ignition system will be necessary to determine which components are at fault.
Car Problem Reports
Mercedes-Benz C220 Bad Spark Plug Wires/Ignition Coils May Cause Misfires and Possible CEL
Mercedes-Benz C220 Problem
Visitor, 1996 Mercedes-Benz C220
Engine light on, no pickup, running very rough. Car was running fine; stopped for a light and then this happened. Glad I made it home!