Failed spark plug wires and/or ignition coils can cause intermittent misfires (rough running); the Check Engine Light may also illuminate. Diagnoses of the ignition system will be necessary to determine which components are at fault.Google+
Car Problem Reports
Mercedes-Benz E55 AMG Bad Spark Plug Wires/Ignition Coils May Cause Misfires and Possible CEL
Mercedes-Benz E55 AMG Problem
Average Mileage: 145,655 mi (126,000 mi - 163,500 mi)
The car runs real rough when I step on the gas in drive. If I shift the car myself it runs better but still mis-fires
Visitor, 2002 Mercedes-Benz E55 AMG, 147,467 mi
Getting a misfire at cylinder 1. Changed spark plugs, ignition coil, and wires at cylinder. Problem fixed.