Check Engine Light and Engine Misfire on Mercedes-Benz E320

Failed spark plug wires and/or ignition coils can cause intermittent misfires (rough running); the Check Engine Light may also illuminate. Diagnoses of the ignition system will be necessary to determine which components are at fault.

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Average mileage: 171,719 (90,500–209,910)
8 model years affected: 1994, 1996, 1997, 1998, more1999, 2000, 2001, 2002
22 people reported this problem
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problem details
1994 Mercedes-Benz E320 175,000 mi,
I have a 1994 E320 that runs great most of the time but from time to time it will run like it's only hitting on 3 cylinders or something. Normally I can cut it off and wait about a minute and it goes back to running fine. This has been going on about a year and it's getting worse. It has 175000 miles
I have a check engine light and codes PO300, 301 and 302. What should I check first after replacing all three coils.
1996 Mercedes-Benz E320 209,500 mi,
Engine misfires. mechanic said it was a bad coil. he replaced one coil but the engine still misfires intermittently. When at the garage, the engine electronics light would not come on and the engine did not skip. The mechanic replaced a coil he thought was bad but it wasn't bad. Now, he can't get a code on which cylinder is misfiring.
Car runs rough and very heavy, especially when it's cold. Has a very bad engine vibration during acceleration.
1997 Mercedes-Benz E320 182,000 mi,
misfire and rough,plugs and coil fix.
2000 Mercedes-Benz E320 131,000 mi,
This is the second time in 2 months the check engine light came on. The first time they had to replace number 4 injector. Now i need to take it back again.
2001 Mercedes-Benz E320 90,500 mi,
Check Engine Light ON and Engine running very rough and rich. Number 4 Cylinder totally out to lunch. Replace all the plugs and wire set and that resolved issue. Recommendation is to replace with Bosch Plugs and Wire Set. Well worth the extra $$.
1999 Mercedes-Benz E320 194,000 mi,
Car start put it in gear govecit gas sputtering n check engine light blinks
1994 Mercedes-Benz E320 209,910 mi,
Rough idle, hesitation, poor acceleration, cutting out at highway speeds. Asked dealer to diagnose. No luck on first visit. On second visit, dealer determined it was bad spark plug wires that were shorting out. All six were replaced and now runs smooth and strong.
Misfire on cyl 3 due to bad spark plug wire. Another time had a bad coil. Was running very rough.