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Q:

1996 Chevy 5.7L 1500 get a misfire on the #1 cylinder what would cause this on 1996 Chevrolet 1500 Pickup

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The engine run fine at times and then starts missing. Is not a repeatable issue that can be repeated by meeting certain criteria. Check engine light comes on and code says misfire #1 cylinder. I hae changed the plug and plug wire. Could this be distributor cap?
(1) Answer
What did the plug look like? that would give you some info on the 'type' of misfire. Fuel/oil/lack of fuel. Look for small intake leak in that area and check inj. wiring carefully.